Objective To explore the effect of a WeChatbased "three good things" positive psychotherapy on job burnout and job performance in nurses. Methods Totally 73 nurses experiencing job burnout symptom were randomized into an intervention group (33 nurses) and a control group (40 nurses). The control group didn′t receive any intervention, while the intervention group received 6 months WeChatbased "three good things" positive psychotherapy. Results The intervention effect, time effect and intervention time interaction effect of burnout between the two groups were significant, and the intervention effect and interaction effect of job dedication, task performance and interpersonal facilitation dimension between the two groups were significant (P<0.05, P<0.01). Conclusion The WeChatbased "three good things" positive psychotherapy is conducive to alleviating nurses′ job burnout, and improving their subjective perceived job performance.