Objective To explore the effect of internet-based continuous nursing care on burden of care in families of children with Kawasaki disease complicated by coronary artery aneurysm. Methods A total of 68 consecutive cases of Kawasaki disease complica-ted with coronary artery aneurysm were selected, and divided into a control group (n=33), who received routine discharge gui-dance, and an intervention group (n=35), who received continuous nursing care through WeChat, QQ, App, etc. Six months after discharge, the Family Burden Interview Scale （FBIS） and Kawasaki Disease Knowledge Questionnaire were used to measure the effect. Results Scores of family daily activities, family recreational activities, family relations, family members′physical and psychological dimensions, and total burden scores were lower, and Kawasaki disease knowledge scores higher, in the intervention group, than those in the control group （P＜0.05,P＜0.01）. Conclusion Continuous nursing care delivered through various internet-based tools can facilitate caregivers′ mastery of the disease and reduce the burden of care in families of children with Kawasaki disease complicated with coronary artery aneurysm.