Objective To establish a standardized SBAR-based handover model for critically ill children to be escorted out of PICU for an examination, and to enhance safety of the children during the process.Methods A total of 150 critically ill children admitted in PICU in January through April, 2018 were assigned into the control group, and received routine measures when escorted out of PICU for an examination. Another 150 critically ill children admitted in PICU in June through September, 2018 were regarded as the observation group, and were handed over based on a standardized SBAR-based handover model to other personnel who escorted them out of PICU for an examination. The incidence rates of out-of-PICU accidents, satisfaction of children′s family in the two groups, medical workers′ satisfaction with out-of-PICU handover communication and cooperation before and after the implement of the standardized SBAR-based handover model, were compared.Results The incidence rates of out-of-PICU accidents were significantly lower, satisfaction of children′s family were significantly higher in the observation group than the control group; medical workers′ satisfaction with out-of-PICU handover communication and cooperation was higher than before (P＜0.01 for all).Conclusion The standardized SBAR-based handover model guaranteed the safety of critically ill children when they were escorted out of PICU for an examination, contributed to a harmony relationship between doctors and patients,and enhanced the communication and cooperation among medical staff.