Objective To explore the feasibility and effect of small private online course (SPOC) combining flipped classroom approach in training of general knowledge and skills for new graduate nurses. Methods A total of 136 new graduate nurses were randomized into a control group of 76 and an observation group of 60, receiving either traditional training or SPOC combining flipped classroom approach. Results The observation group had higher exam scores of technical skills and clinical application, as well as higher satisfaction with the training compared with the control group(P<0.01 for all). Conclusion The combination use of SPOC and flipped classroom approach in training of general knowledge and skills for new graduate nurses, facilitates to inspire nurses′ interest in learning, and improves their technical skill and clinical application ability.