Objective To reduce nursing interruptions in obstetric unit. Methods Sixteen nurses working in obstetric department were observed during rush hours to identity interruptions in their work, and then interventions were taken to manage the interruptions. The number of interruptions, interruption duration, and outcomes of the interruption were compared before and after the intervention. Results The interruptions were decreased, interruption duration was shortened, negative outcomes and adverse events due to interruptions were reduced, with significant differences before and after the intervention (P<0.01 for all). Conclusion Interventions targeted to specific interruptions can reduce the occurrence of interruptions and adverse nursing events.