Objective To explore the effects of aerobic and resistance exercise on cardiac pump function and tissue microcirculation of patients with coronary heart disease, and to provide reference for cardiac rehabilitation. MethodsA total of 82 patients with coronary heart disease were divided into two groups chronologically, with 41 cases in each groups. The control group was subjected to traditional nursing care and exercise education, while the study group received a combined aerobic and resistance exercise program additionally. The effects were measured after 12 weeks of intervention. Results The study group had better cardiac, vascular and hematologic function, as well as better tissue microcirculation compared with the control group (P<0.01 for all). ConclusionA combined aerobic and resistance exercise program can effectively improve cardiac pump function and tissue microcirculation of patients with coronary heart disease.