Objective To evaluatesy stematic reviews on ICU acquired weakness, and to provide basis for development of evidence-based nursing practice programs which aims at preventing ICU acquired weakness. Methods Overviews of current systematic reviews or Meta-analysis on ICU acquired weakness were carried out. Results Fifteen systematic reviews or meta-analysis which involved such 5 aspects of ICU acquired weakness as risk factors,incidence, assessment and diagnosis, prevention, and treatment, were included.The publications scored 4-7 points in methodological quality.Totally, 43 pieces of evidence were extracted, of which, 7 pieces were at high level, 13 medium level,18 low level, and 5 lowest level. Conclusion The overviews of systematic reviews sums up evidence regarding risk factors, incidence, assessment and diagnosis, prevention, and treatment of ICU acquired weakness, and provides reliable evidence support for the construction of evidence-based nursing practice program aiming at preventing ICU acquired weakness.