Objective To explore the effect of continuous care intervention based on timing it right (TIR) framework on postpartum depression. Methods A total of 101 patients were randomly divided into an intervention group （n=50） and a control group （n=51）.The control group received routine obstetric nursing care, while the intervention group were given TIR framework based continuous care intervention.The Edinburgh Postnatal Depression Scale and the General Self-Efficacy Scale were used to measure the participants before intervention, on the day of discharge,and 3 months after delivery; and the Mother Role Adaptation Questionnaire was used to evaluation the participants at 3 months after delivery. Results Three months after delivery, the intervention group had lower scores and incidence rate of depression, and higher self-efficacy scores and mother role adaptation scores （P＜0.05,P＜0.01）. Conclusion TIR framework based continuous care intervention could effectively improve self-efficacy of postpartal women and their adaptability of the mother′s role, therefore prevent the incidence rate of postpartum depression.