Objective To describe the level of resilience among women with gestational diabetes mellitus (GDM) and to explore its related factors. Methods A total of 359 women with GDM were selected from obstetric outpatient clinics of 4 tertiary hospitals in Shanghai and were invited to complete the ConnorDavidson Resilience Scale, selfdesigned GDM knowledge, attitude, and practice (KAP) questionnaire and demographic data questionnaire. Results The sample scored 69.99±15.03 on resilience, which was positively correlated with the GDM knowledge, attitude, and practice scores respectively (P<0.01 for all). Hospital, gestational age, insulin use, GDM knowledge, attitude, and practice were influencing factors of resilience (P<0.05, P<0.01), which could explain 37.7% of the total variance. Conclusion The resilience of women with GDM was at medium level and affected by hospital, gestational age, insulin use and GDM knowledge, attitude and practice. Standardized blood glucose management should be provided, mental health of women during early or late pregnancy and of those who use insulin should be paid more attention, and their GDM knowledge, attitude and practice should be improved, thus to enhance their resilience.