Objective To improve the teaching outcomes of the course of Multicultural Nursing. MethodsA total of 33 undergraduate nursing students were enrolled in this study and received teaching activities by employing foreign standardized patient in the course of Multicultural Nursing for 15 teaching hours, including cultural interview and videotaping of the simulated scenarios, etc. ResultsThe examination score of the course was 72.73±7.01. The 3 dimension scores of transcultural nursing selfefficacy were significantly improved after the teaching （P＜0.05，P＜0.01）. About 53.3% to 83.3% of the students gave positive feedbacks on the use of foreign standardized patient in the teaching. ConclusionThe use of foreign standardized patient in the course of Multicultural Nursing effectively guarantees teaching effect and enhances students′ transcultural nursing selfefficacy.