Objective To evaluate the effect of Jian Pi Yi Shen (spleenkidney nourishing) porridge on relief of fatigue and improvement of quality of life in patients with chronic fatigue syndrome (CFS) of spleen and kidney Yang deficiency. Methods Eightysix CFS patients with spleen and kidney Yang deficiency were randomized into two groups, with 43 cases in each group. The control group was given both onetoone and groupbased diseaserelated knowledge and dietary education, while the observation group additionally received spleenkidney nourishing porridge once every two days. Effect was measured after 8 weeks of intervention. Results The fatigue severity score was significantly lower, whereas the total 36item shortform health survey (SF36) score and 7 dimension scores (except general health perceptions) were significantly higher in the observation group compared with the control group after the intervention (P<0.01 for all). Conclusions Jian Pi Yi Shen porridge can alleviate fatigue and improve quality of life of patients with CFS of spleen and kidney Yang deficiency.