Objective To explore the effects of mobile App supported intermediate care on selfcare agency and quality of life of patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods Totally, 82 AMI patients after PCI were randomized into two group, with 41 in each group. The control group was given traditional discharge guidance and telephone followup, while their counterparts in the intervention group received mobile App supported intermediate care for 4 weeks. Selfcare agency and quality of life were compared between the two groups before and after the intervention. Results Selfcare agency and quality of life were significantly higher in the intervention group than those in the control group after the intervention （P＜0.05, P<0.01）. Conclusion Mobile App supported intermediate care can improve selfcare agency and quality of life of patients with AMI acute PCI.