Objective To develop patientreported outcome (PRO) information system for adult strabismus based on computer adaptive testing （CAT）， and to evaluate its application effect. Methods Following the guidance that was approved by the U.S.Food and Drug Administration for developing PRO instrument, we employed qualitative research, Delphi process and the Rasch model to establish the item pool, then we used CAT to create the information system which included three core modules as assessment, statistics, and system management. A total of 101 adults with strabismus were assessed by the information system (the system group) and effect was compared with 100 controls who were assessed using paper sheets (the control group). ResultsThe system group used shorter time to assess, and had higher patient satisfaction and compliance with the assessment (P<0.05,P<0.01). Conclusion The CATassisted PRO information system can reduce assessment time and improve patient satisfaction and compliance.