Objective To compile the Stroke Stigma Scale, to test its reliability and validity, and to provide an evaluation tool for measuring stigma of stroke patients. Methods On the basis of qualitative interviews and literature review, an item pool was formed according to the theoretical framework of stigma perception in stroke patients.The original scale was formed after consultation. A total of 288 inpatients with stroke were selected, and were investigated by the original scale. Results The Stroke Stigma Scale consisted of 4 dimensions, totaling 16 items. The content validity indexes of the items ranged from 0.910 to 1.000, and the content validity index of the scale was 0.989. Four factors (physical disorder, social interaction, experience of discrimination and self-perception) were extracted through exploratory factor analysis, while the cumulative contribution rate of variance was 68.051%.There was a positive correlation between total and dimension scores of stigma and scores of anxiety (all P＜0.01). The Cronbach′s α coefficient was 0.916 for the scale, and 0.771-0.864 for the dimensions.The retest reliability coefficient was 0.924 for the scale (P＜0.01), and 0.735-0.886 for the dimensions (all P＜0.01). Conclusion The Stroke Stigma Scale is reliable and valid, which can serve as an objective tool to evaluate stigma of stroke patients from four aspects: physical impairment, social communication, experience of discrimination and self-perception.