Objective To explore the effect of meridian moxibustion combined with barometric therapy based on the Midnight-moon Ebb-flow Theory on the swelling degree, pain, and quality of life of patients with breast cancer-related lymphedema.Methods A total of 70 patients with breast cancer-related lymphedema were randomly divided into a control group (n=35) and an observation group (n=35).The control group received routine health education and barometric therapy on the affected limb (30 minutes each time), while the observation group was subjected to meridian moxibustion intervention based on the Midnight-moon Ebb-flow Theory in addition to the control group′s treatment.Both groups were treated twice a week for four weeks.The affected limb swel-ling, pain, and upper limb lymphedema quality of life of both groups were assessed before and after the intervention, respectively.Results A total of 30 cases in each group completed the study.After the intervention, the limb swelling degree and scores of pain and the upper limb lymphedema quality of life of the observation group were significantly lower than those of the control group (all P＜0.05).Conclusion Meridian moxibustion based on the Midnight-noon Ebb-flow Theory combine with barometric therapy can effectively improve the symptoms of patients with breast cancer-related lymphedema and enhance the quality of life.