Objective To investigate the symptom clusters and quality of life of patients undergoing bladder irrigation chemotherapy at diffe-rent time points, and to analyze the longitudinal correlation between the two, to provide a reference for clinical dynamic management of symptom clusters.Methods Convenience sampling was used to select patients undergoing bladder irrigation chemotherapy from October 2023 to June 2024 as the research participants.Data were collected using the Bladder Irrigation Symptom Assessment Questionnaire and the Function Assessment of Cancer Therapy-Bladder (FACT-BL) after the 1st （T1）, 4th （T2）, and 8th (T3) of the bladder irrigations of the patients, respectively.Results Patients undergoing bladder irrigation chemotherapy had urinary system symptom clusters, digestive system symptom clusters, somatic symptom clusters, and psychological symptom clusters at T1-T3; among them, the urinary system and psychological symptom clusters showed an increasing then decreasing trend, the somatic symptom clusters showed an increasing trend, and the digestive system symptom clusters showed a decreasing trend.There were statistically significant differences in the scores of symptom clusters and quality of life at the three time points (all P＜0.05).The symptom clusters and the dimensions of quality of life of bladder irrigation patients at T1-T3 were negatively correlated, and the correlation also showed a dynamic trend (all P＜0.05).Conclusion Patients undergoing bladder irrigation chemotherapy have multiple symptom clusters, which are relatively stable but also dynamically changing, and the severity of the symptom clusters is closely related to the patients′ quality of life.Medical staff should pay attention to the dynamic management of symptom clusters in patients undergoing bladder irrigation chemotherapy to alleviate symptom burden and improve their quality of life.