Objective To explore the perception of medical staff regarding the role of non-clinical support personnel in patient safety management based on the Theoretical Domains Framework (TDF), and to provide a scientific basis for patient safety improvement.Methods A descriptive qualitative research method was employed, selecting 29 clinical healthcare personnel through purposive sampling.Semi-structured in-depth interviews were conducted.The interview guide was designed based on the TDF, and themes were extracted using content analysis.Results Five themes were identified:differences in role perception, individual characteristics affecting performance, lack of knowledge and skills, ambiguity of reward and punishment mechanisms, and safety culture incentives.Conclusion Medical staff generally recognize the importance of non-clinical support personnel in patient safety; however, va-rious factors influence the performance of the support personnel.It is recommended to enhance the participation ability and willingness of non-clinical support personnel through measures such as perception, leveraging individual strengths, establishing a learning organization, and constructing an efficient incentive and accountability system.