Objective To summarize the best evidence regarding non-pharmacological interventions for fertility anxiety in women of childbearing age with breast cancer, and to provide a reference for healthcare professionals to develop evidence-based interventions.Methods Following the "6S" evidence model, a comprehensive search was conducted across clinical decision support systems, databases, guidelines, and professional association websites for all evidence related to non-pharmacological interventions for fertility anxiety in women of childbearing age with breast cancer, including guidelines, clinical decisions, evidence summaries, expert consensus, systematic reviews, and randomized controlled trials. Two researchers independently conducted literature screening and quality assessment, extracting, summarizing, and sorting out the evidence from qualified studies.Results A total of 9 articles were included, consisting of 1 guideline, 3 expert consensus documents, 2 systematic reviews, and 3 randomized controlled trials.A total of 21 pieces of evidence related to non-pharmacological interventions for fertility anxiety were extracted and categorized into 7 themes:assessment of risk factors and psychological status, informational support, psychological interventions, exercise therapy, self-expression, family social support, and multidisciplinary strategies.Conclusion It is recommended that clinical non-pharmacological intervention programs for fertility anxiety in women of childbearing age with breast cancer be developed and implemented based on the best evidence, considering clinical context, professional skills, and patient preferences, in an effort to alleviate fertility anxiety levels in this population.