Objective To explore the effectiveness of the micro-media digital interactive platform combined with virtual simulation and escape room techniques in emergency first aid training for non-medical students. Methods Two classes (n=88) of the Grade 2022 in a three-year high-speed rail passenger service major were served as the control group, and two classes (n=90) of the Grade 2023 were treated as the experimental group. The control group received traditional teaching methods, while the experimental group used a blended teaching model, incorporating the micro-media digital interactive platform, online virtual simulation training, and offline escape room activities. Results The experimental group showed significantly higher scores in theoretical and skills assessments, learning involvement, and critical thinking ability compared to the control group (all P<0.05). Conclusion The use of the micro-media digital interactive platform combined with virtual simulation and escape room techniques in emergency first aid training for non-medical students can stimulate student engagement, enhance critical thinking ability, and improve teaching outcomes.