Objective To explore the application effect of video microteaching combined with Teach-back education mode in patients with Crohn′s disease with indwelling nasoenteric tube for total enteral nutrition.Methods A total of 90 patients with Crohn′s disease with indwelling nasoenteric tube for total enteral nutrition who were admitted to the Department of Gastroenterology from July 2023 to June 2024 were selected by convenience sampling method, and were divided into control group （49 cases） and intervention group （41 cases） according to the time of admission.The control group received routine health education, and the intervention group was carried out the video microteaching combined with the Teach-back education mode.The quality of life, nutrition-related indexes and nasoenteric tube blockage rate were compared between the two groups before and after the intervention.Results After 6 weeks of follow-up, the scores of Inflammatory Bowel Disease Questionnaire (IBDQ) in all dimensions and total scores in the intervention group were higher than those in the control group, the levels of hemoglobin, prealbumin, albumin and body mass index in the intervention group were higher than those in the control group, and the occlusion rate in the intervention group was significantly lower than that in the control group （all P＜0.05）.Conclusion The application of video microclasses combined with Teach-back education model in the care of patients with Crohn′s disease on total enteral nutrition can improve the quality of life of the patients, improve the nutritional status, and reduce the rate of tube blockage, which is conducive to the improvement of the survival outcome of the patients.