Objective To summarize the best evidence for re-suicide risk management in emergency department patients with suicide attempts, and to provide an evidence-based basis for clinical suicide prevention research or clinical practice in this population.Methods A systematic search was conducted according to the "6S" pyramid model, focusing on evidence types such as guidelines, best practices, clinical decisions, systematic reviews, evidence summaries, and expert consensus.The search covered literature from database inception to March 2024. Two researchers independently screened the literature and assessed its quality.Evidence was then extracted, synthesized, and summarized according to the themes.Results A total of 18 articles were finally included, containing 1 best practice, 2 clinical decisions, 2 guidelines, 3 pieces expert consensus, and 10 systematic reviews.A total of 27 pieces of evidence related to re-suicide risk management in emergency patients with suicide attempts were extracted and summarized into 5 themes:organizational support, rapid treatment, suicide assessment, interventions, and follow-up and referral.Conclusion Healthcare professionals should apply evidence judiciously in the context of the domestic clinical situation, while building a multidisciplinary collaborative mechanism to expand the support system for emergency department patients with suicide attempts, thereby reducing the risk of re-suicide in patients.