Objective To explore the effect of clinical translation of Medical Adhesive-related Skin Injury （MARSI） prevention evidence in adult ICU patients, and to provide a basis for conducting related research.Methods A total of 394 patients were divided into a baseline review group, a round 1 evidence application group, a round 2 evidence application group, and a round 3 evidence application group according to their hospitalization time, with 94 cases in each group.Using the CLARITY cycle as a guide, the 29 screened best evidence for MARSI prevention in adult ICU patients were applied in 3 rounds of clinical application.Results The overall compliance rate of the review metrics increased from 11.11% to 81.48%; the total knowledge score of ICU nurses on MARSI prevention increased from 55.0 (43.8, 60.0) to 90 (78.8,95.0); the incidence of MARSI in ICU patients decreased from 20.21% to 3.19%; and the difference between ICU treatment costs and medical adhesive-related costs were not statistically signi-ficant (all P＞0.05); the difference in patient family satisfaction was statistically significant (P＜0.05). At the system level, the process of using and removing medical adhesive was added, and the application effect were continuously tested.Conclusion Carrying out the evidence-based practice of prevention and management of MARSI in adult ICU patients can improve the implementation rate of various review indicators and the mastery of prevention knowledge among ICU nurses, reduce the incidence of MARSI, improve the satisfaction of patients′ families, and promote the scientific transformation of the best evidence to clinical practice.