Objective To retrieve, evaluate, and integrate evidence related to intraosseous infusion in critically ill shocked children, and to provide evidence support for accurate implementation of intraosseous infusion. Methods Relevant databases were searched for evidence on the treatment of intraosseous infusion in critically ill shocked children, including clinical decisions, guidelines, expert consensus, systematic reviews, evidence summaries, and randomized controlled trials.The retrieval timeframe was from the establishment of the database to May 2024.Results A total of 8 publications were included, containing 1 clinical decision, 1 guideline, 3 expert consensus reports, 2 systematic reviews, and 1 randomized controlled trial.A total of 40 pieces of evidence were summarized into 10 areas, including indications and contraindications for intraosseous infusion access, puncture equipment, puncture site, skin disinfection, nature of the drug, speed of infusion, removal of intraosseous infusion access, pain management, prevention and management of complications, operation qualification, and education and training.Conclusion This study summarizes the best evidence for intraosseous infusion in critically ill shocked children, which can provide reference for healthcare professionals to accurately implement intraosseous infusion, and it is recommended that healthcare professionals apply the evidence according to the clinical scenarios and the actual situation of the child.