Objective To explore the application effects of perioperative nutrition program for gastric cancer patients with sarcopenia.Methods Based on literature review and group interviews, the first draft of nutrition program was formed, and two rounds of expert consultation were conducted by Delphi method to form the perioperative nutrition program for gastric cancer patients with sarcopenia.A total of 53 gastric cancer patients with sarcopenia were selected by convenient sampling method and divided into the control group (n=27) and the experimental group (n=26) according to the admission time.The control group was given routine nutrition nursing intervention, while the experimental group was given the perioperative nutrition program.The effects were evaluated before operation, 5 days after operation and 1 month after discharge of the patients.Results Comparison of serum albumin and total protein, limb skeletal muscle mass index, and grip strength between two groups at different time showed statistically significant differences in inter group effects (excluding grip strength), time effects, and interaction effects (all P＜0.05).Conclusion Implementing the nutritional program during the perioperative period can improve the postoperative nutritional status of the gastric can-cer patients with sarcopenia, and enhance their muscle strength level.