Objective To explore the application effect of nursing plan based on Swanson′s care theory in patients with chronic osteomyelitis, and provide reference for improving patients′ positive psychological state and humanistic nursing experience. Methods Convenience sampling was used to select 74 patients with chronic osteomyelitis as the research subjects from May to November 2023. They were divided into a control group and an intervention group, with 37 patients in each group according to different disease wards. The control group received routine psychological care, while the intervention group received a nursing plan based on Swanson′s care theory. The Well-Being inWounds Inventory(WOWI), Exercise of Self-Care Agency (ESCA) Scale, Client Perception of Caring Scale (CPCS) and 14-item Resilience-Scale (RS-14) were used to evaluate the intervention effect. Results After intervention, the intervention group showed significantly higher levels of WOWI, self-care ability, perceived care score, and psychological resilience compared to the control group (all P<0.05). Conclusion A nursing plan based on Swanson′s care theory can enhance the positive psychological state and resilience level of patients with chronic osteomyelitis, improve self-care ability, and enhance patients′ perception of humanistic care.