Objective To develop a medical device related pressure injury risk assessment scale for adult inpatients, and to test its reliability and validity, so as to provide a reference for accurately and objectively assessing the risk of medical device related pressure injury in adult inpatients.Methods A draft medical device related pressure injury risk assessment scale was formed based on relevant literature and guidelines, combined with Delphi expert consultation and pre-test, then it was used to investigate 550 adult inpatients to test its reliability and validity.Results The Final Medical Device Related Pressure Injury Risk Assessment Scale consisted of 5 dimensions and 17 items. Exploratory factor analysis extracted five factors with a cumulative variance contribution of 69.444%.The Cronbach′s alpha coefficient for the total scale was 0.861, with a fold-half reliability of 0.743.The area under the subject′s operating characteristic curve was 0.893［95%CI（0.849，0.938），P＜0.05］, and the optimal high-risk threshold was 36.5, which corresponded to a sensitivity of 0.961 and a specificity of 0.724.Conclusion The Medical Device Related Pressure Injury Risk Assessment Scale for adult inpatients has good reliability and validity, it can be used as a tool to screen adult inpatients at high risk of medical device related pressure injury.