Objective To explore the application effect of site-based micro-video health education in perioperative patients with traumatic fractures. Methods From October 2023 to March 2024, a total of 163 patients with traumatic fractures in the Department of Orthopedic Trauma were divided into a control group (81 cases) and an intervention group (82 cases) chronologically. The control group was provided perioperative health education using conventional method, while the intervention group received site-based micro-video health education, including 5 major sites with 6 micro videos in accordance with time line and 9 micro videos focusing on specialized modules in major sites. The 15 micro videos covered the time points of admission, preoperation, intraoperation, post operation and discharge. Results Eighty patients in each group completed the study and follow-up. At discharge and 1 month after discharge, the scores of acknowledgement of related knowledge, self-efficacy, and daily living ability in the intervention group were significantly higher than those of the control group, and its score of disease uncertainty was significantly lower than that of the control group (all P<0.05). At discharge, the incidence of venous thromboembolism and moderate to severe pain during the perio-perative period of the intervention group were significantly lower than those of the control group, and its satisfaction scoring of health education was significantly higher than that of the control group (all P<0.05). The nurses′ satisfaction regarding improved health education methods was 100%. Conclusion Site-based micro-video health education can optimize the perioperative procedure of orthopedic patients, improve patients′ acknowledgement of disease related knowledge, reduce complication rates, and improve their healthcare experiences.