Objective To develop and preliminarily validate a brief cognitive behaviour intervention program for suicide prevention tailored to cervical cancer patients, so as to provide references for prevention and management of suicide in cancer patients. Methods A brief cognitive behaviour intervention program for suicide prevention in cervical cancer patients was developed based on Dr.Gillihan′s 7-week cognitive behaviour therapy, supplemented by a summary of evidence and expert meeting. A non-randomized controlled design was used. A total of 26 cervical cancer patients from the gynecological oncology department of a tertiary hospital from May to June 2023 were assigned to an intervention group (n=13) or a control group (n=13) based on ward allocation. The control group received routine nursing care along with general psychological interventions, while the intervention group additionally received the brief cognitive behaviour intervention program, which included setting goals and planning actions, establishing new thinking patterns, regaining vitality, improving quality of life, facing the fear of recurrence, making a safety plan, and integrating all elements into daily life, with a total duration of less than 7 hours. Data on suicidal ideation, depression, gastrointestinal system adverse reactions, urinary system adverse reactions, and quality of life were collected at three time points:pre-intervention, post-intervention, and 1 month after the intervention. Results In the intervention group, the retention rate was 100%, acceptability was 100%, adherence to assigned homework ranged from 30.77% to 100%. After the intervention, in the intervention group, the scores of suicidal ideation, depression, adverse digestive system reactions were significantly lower than those before the intervention and in the control group, while its scores of quality of life were significantly higher than those before the intervention and in the control group (all P<0.05). Conclusion The brief cognitive behaviour intervention program for suicide prevention in cervical cancer patients demonstrates feasibility and high acceptance. Its application effectively reduces suicide risk, improves quality of life, and offers valuable insights for clinical psychological practice.