Objective To understand the changes of care needs of caregivers of high-risk infants during the period from hospital admission to family return after discharge, and to provide reference for formulating intervention plan for these caregivers to prepare for discharge.Methods Three semi-structured interviews were conducted with 14 caregivers of high-risk infants by purposive sampling method.The interviews were conducted within 3 days of admission, at the time of discharge, and 1 month after discharge.The method of longitudinal qualitative research was adopted.After each interview, Smith interpretive phenomenological analysis method was used to analyze the data synchronically.After all the data were collected, the overall longitudinal diachronic analysis was carried out.Results The data were summarized and three themes and eight sub-themes were extracted, namely:the need for information and emotional connection during admission (the need for information on breastfeeding, the need for information on di-sease progression, and the need for emotional connection), the need for continuity of care services during hospital discharge planing (the need for communication on online platforms, the need for guidance on the selection of milk powder and the use of medication, and the need for guidance on special check-ups), and the need for care support (the need for information on professional care, the need for family social support, and the need for professional support).Care support during return to family (need for professional care information support, need for family social support).Conclusion The needs of caregivers of high-risk infants are dynamically changing, and medical staff should formulate targeted intervention programs for the preparation of caregivers for discharge accor-ding to the needs of caregivers at different periods.