Objective To understand the current situation of ethical sensitivity among oncology nurses，to analyze its influencing factors, and to provide references for formulating targeted intervention measures. Methods Convenience sampling method was employed to select 882 oncology nurses from 10 tertiary hospitals in 10 provinces across China as survey participants. An online questionnaire survey was conducted using the general information questionnaire, the Moral Sensitivity Questionnaire-revised Chinese version, and the Cultural Intelligence Scale. Results The score of ethical sensitivity of oncology nurses was (41.17±6.41) points, and the score of cultural intelligence was (96.25±19.70) points. The results of multiple linear regression analysis showed that marital status, human resources in the department, and cultural intelligence were the influencing factors of ethical sensitivity among oncology nurses (all P<0.05). Conclusion The ethical sensitivity of oncology nurses is at an above-average level. It is recommended that nursing managers care for nurses who are divorced, rationally allocate nursing human resources, and improve the cultural intelligence level of nurses to help enhance ethical sensitivity.