Objective To explore the effect of intelligent self-management prescription in patients with diabetes mellitus.Methods A total of 360 diabetes patients were randomized into two groups, with 180 in each.The control group received self-management education and support through an intelligent management platform, while their counterparts in the intervention group additionally received self-management prescription which was generated by analyzing patient′s individualized conditions with an intelligent decision support system.The prescription included 6 parts:assessment, diet, exercise, monitoring, education and complication prevention.The blood glucose, treatment compliance and self-management behaviors were compared between the two groups immediately post 6-month.Results The levels of fasting blood glucose, 2 h postprandial glucose and glycosylated hemoglobin (HbA1c) were significantly lower, whereas treatment compliance and self-management behaviors (except smoking) were significantly higher in the intervention group compared with the control group immediately post intervention （all P＜0.05）.Conclusion Implementing intelligent self-management prescription in diabetes patients can enhance their treatment compliance and self-management behavior, resulting in improving blood glucose control.