Objective To observe the effectiveness of modified McNeil Dysphagia Therapy Program on stroke patients with dysphagia, and to provide a new method for clinical intervention. Methods A total of 64 stroke patients with dysphagia were randomly divided into 32 cases each in the control group and the intervention group. The control group received routine rehabilitation care and swallowing training, while the intervention group received routine rehabilitation care and modified McNeil Swallowing Therapy Program. After 3 weeks of the intervention,the swallowing function, nutritional risk, and clinical efficacy of the two groups were compared. Results After the intervention, the swallowing function and clinical efficacy of the intervention group were significantly higher than those of the control group, and the nutritional risk level of the intervention group was significantly lower than that of the control group (all P<0.05). Conclusion The modified McNeil Swallowing Therapy Program can effectively improve the swallowing function of patients, reduce the nutritional risk, and promote the patients′ recovery.