Objective To investigate the components and dynamic changes of symptom clusters in patients with multiple myeloma during chemotherapy cycles, and to explore the relationships between symptoms within clusters through symptom network, so as to provide evidence for symptom management.Methods A convenience sample of 175 patients newly diagnosed with multiple myeloma were recruited and surveyed using a general information questionnaire and the Chinese version of Memorial Symptom Assessment Scale before induction chemotherapy and at completion of the 1st to 4th cycle of chemotherapy.Exploratory factor analysis was performed to extract symptom clusters.R software was used to construct symptom networks and analyze centrality measures.Results Four common symptom clusters were identified at different chemotherapy cycles:psychological, disease behavior, fatigue related, and digestive tract.The most central symptom was worry during pre-chemotherapy stage and during the intermittent pe-riod of the first three cycles of chemotherapy, and was distress during the intermittent period of the 4th cycle.Both of the above two symptoms were in the psychological symptom cluster.Conclusion The symptom clusters are relatively stable during different che-motherapy cycles and also exhibit dynamic changes.Medical staff need to conduct interventions on those stable symptom clusters and central symptoms, so as to improve the accuracy and efficiency of symptom management, and to alleviate symptom burden of patients.