Objective To analyse the current situation and influencing factors of social isolation in disabled older adults and to provide reference for constructing social isolation intervention of disabled older adults. Methods A total of 483 disabled older adults from two communities in Lu'an were selected by multistage stratified cluster sampling. The Barthel Index ,Instrumental Activities of Daily Living scale and the Lubben Social Network Scale were used to survey.Individual, behavioral and environmental factors of the disabled older adults were collected simultaneously.Variables were filtered by using LASSO regression.Multivariate logistic regression was used to analyse the filtered factors. Results The incidence rate of social isolation among disabled older adults was 48.86%. Multivariate logistic regression analysis showed that gender, education level, sleep efficiency, physical activity level, residence were factors affecting social isolation of disabled older adults (P＜0.05 for all). Conclusion Social isolation of disabled older adults was at a higher level. Community nursing workers should pay attention to the disabled older adults with high risk of social isolation, and take intervention according to the influencing factors to reduce the incidence of social isolation in disabled older adults.