Objective To explore the relationship between developmental human resource practices (DHRP) and voice behavior among nurses and the mediating role of career resilience.Methods A convenience sample of 328 nurses from 7 tertiary Grade A hospitals in Henan Province were surveyed using the Developmental Human Resource Practices Scale, the Career Resilience Scale and the Voice Behavior Scale.AMOS26.0 software was used to construct the mediating effect model.Results The sample scored (68.70±6.26) for DHRP, (94.16±8.80) for career resilience, and (33.65±8.35) for voice behavior.Career resilience partially mediated the relationship between DHRP and voice behavior, accounting for 54.5% of the total effect.Conclusion DHRP of the hospital, as well as nurses′ career resilience and voice behavior are at moderate levels.DHRP can directly or indirectly (through career resilience) affect nurses′voice behavior.Hospital managers should adopt DHRP and enhance career resilience of nurses, so as to improve their voice behavior.