Objective To explore the effect of a psychological prescription intervention on reducing the psychological stress in caregi-vers of children with newly diagnosed sarcoma.Methods Fifty caregivers of children with newly diagnosed sarcoma hospitalizing from May 2021 to May 2022 were allocated to a control group and received routine psychological care and intervention, while 49 caregivers of children with newly diagnosed sarcoma hospitalizing from June 2022 to May 2023 were regarded as an experimental group and additionally received a psychological prescription intervention, which consisted of 6 psychological component:in-depth interviews, mindfulness meditation, mindfulness breathing, parent-child sand play therapy, parent-child aromatherapy, and pa-rents group discussion, lasting for 4 weeks.Results Forty-eight caregivers in each group completed the study.After the intervention, the total scores of the Generalized Anxiety Disorder-7 and the Stress Response Questionnaire and its three subscale scores of the experimental group were significantly lower than those of the control group ( all P＜0.05).Conclusion The psychological prescription intervention is conducive to reducing the anxiety and stress response of the caregivers of children with newly diagnosed sarcoma, adjusting their psychological stress state, meeting their care needs, and improving their care experience.