Objective To explore the application effect of the Project Based Group Study (PBGS) combined with flipped classroom in the course of Nursing Research.Methods Undergraduate nursing students from four parallel classes enrolled in 2019 were assigned to a control group and an intervention group by cluster randomization, with 103 students in each group.In the teaching of Nursing Research, the control group adopted traditional teaching method, while the intervention group were taught by using the learning model of PBGS combined with flipped classroom.Results Except for the objective questions in the final exam, the scores of subjective questions in mid-term and final exam and scores of grant proposal writing of scientific research project of the intervention group were significantly higher than those of the control group (all P＜0.05).After the course, the intervention group scored significantly higher in self-directed learning ability than that before the course (P＜0.05).Conclusion The blended teaching model of PBGS combined with flipped classroom can improve students′ learning performance in the course of Nursing Research.