Objective To investigate the core competencies of ICU nurses in regional medical consortium hospitals, and to analyze its influencing factors, so as to provide a reference for developing targeted intervention to improve the core competencies of this population.Methods A total of 285 ICU nurses from 19 hospitals in the Huanggang medical consortium were selected using cluster sampling method, then they were investigated by using a general information questionnaire, the Nurses′ Perceived Professional Benefits Scale and the ICU Nurse Core Competence Scale.Results The participants′ total score of core competencies was (258.79±65.11), its item average score was (3.50±0.88), with the subscale of clinical practice ability scoring the highest (3.70±0.92), and the subscale of professional development ability scoring the lowest (3.28±0.95).The nurses′ total score of professional benefits was (53.75±10.86).Grade of the working hospital, professional title, participated in ICU specialist training, obtained ICU specialist nurse certificate, job security and work value were the main influencing factors of the core competencies among ICU nurses in regional medical consortium hospitals ( all P＜0.05).Conclusion The core competencies of ICU nurses in medical consortium hospitals is at a medium level.It is necessary to provide specialized training for ICU nurses and improve their perceived professional benefits, so as to improve their core competencies.