Objective To implement a midwife-led maternity care program and to evaluate its effectiveness for low-risk pregnant women.Methods Low-risk pregnant women who made an appointment at a tertiary obstetrics and gynecology hospital in Shanghai were selected as the study objects, and were randomly divided into an intervention group （n=485） and a control group （n=499）.The control group received routine prenatal health services led by obstetricians, and routine obstetric care services were performed during intrapartum and postpartum periods, while the intervention group additionally received a midwife-led maternity care program, including eight antenatal contacts in the midwife′s outpatient clinic, WeChat group intervention and telephone visits, conti-nuous labor support and postpartum visits.Results In the intervention group, the median number of antenatal contacts with midwives was 7 times.The rate of birth plan making and its implementation rate were 76.70% and 84.68%, respectively.Women in the intervention group experienced lower cesarean section rate （27.68%） than that in the control group （35.25%）（P＜0.05）.Women in the intervention group experienced lower chances of epidural analgesia, amniotomy, episiotomy and NICU admission, less amount of bleeding in the third stage of labor and 2 hours postpartum, and less amount of total bleeding （all P＜0.05）.The total scores of women′s antenatal care experience, childbirth experience, postnatal care experience, reproductive health literacy in late trimester, antenatal breast-feeding self-efficacy, childbirth self-efficacy, and the rate of exclusive breastfeeding before discharge were all significantly higher in the intervention group than those in the control group （all P＜0.05）.Conclusion The implementation of the midwife-led maternity care program can promote low-risk women′s normal pregnancy and childbirth, improve women′s ante-, intra-, and postnatal care experience, and achieve the two-way empowerment between women and midwives.