Objective To explore the effects of white noise combined with grip ball intervention in patients with atrial fibrillation du-ring radiofrequency ablation.Methods A total of 177 atrial fibrillation patients undergoing radiofrequency ablation were randomized into a control group, a grip ball group and a combined group using a random number table, with 59 patients in each group.During radiofrequency ablation, the control group received routine nursing, the grip ball group additionally held a grip ball to pinch and squeeze when they were not comfortable, and the combined group, on the basis of the grip ball group, worn earphones to play the pre-selected white noise music when they entered the operating room.Results In the three groups, 51, 52 and 50 patients completed the study, respectively.After the intervention, at 10 minute of radiofrequency ablation (T2), and ablation to the anterior and posterior walls of the right and left pulmonary veins (T3,T4), there were statistically significant differences in the scores of pain and anxiety, and the total dose of fentanyl among the three groups, which were significantly lower or less in the combined group than those in the other two groups ( all P＜0.05).Comparison of the vital signs among the three groups at T2, T3 and T4 showed statistically significant differences, and the stability of heart rate and systolic blood pressure of the combined group was better than those of the grip ball group and the control group ( both P＜0.05).Conclusion The intervention of white noise combined with grip ball can effectively alleviate pain and anxiety in patients with atrial fibrillation during radiofrequency ablation, and maintain the stability of their vital signs.