Objective To construct a social isolation intervention scheme for the young and middle-aged stroke patients with motor dysfunction, and to evaluate its application effects.Methods Guided by the Capability, Opportunity, Motivation- Behaviour (COM-B) model, a social isolation intervention scheme for the young and middle-aged stroke patients with motor dysfunction was constructed based on semi-structured interviews and cross-sectional study exploring the barriers and enablers of social isolation and patients′ demands of improving the status of social isolation.Then a total of 78 young and middle-aged stroke patients with motor dysfunction were divided into a control group and an experimental group according to wards, with 39 patients in each group.The control group were given routine nursing and follow-up, while the experimental group additionally received the social isolation intervention scheme until 4 weeks after discharge.Results A total of 39 cases in the control group and 36 cases in the experimental group completed the study.After the intervention, the scores of the General Alienation Scale and the Hospital Anxiety and Depression Scale in the experimental group were significantly lower than those of the control group, while its score of the Perceived Social Support Scale was significantly higher than that of the control group (all P＜0.05）.Conclusion Implementation of the social isolation intervention scheme for the young and middle-aged stroke patients with motor dysfunction is conducive to alleviating anxiety and depression, improve their perceived social support, and reduce the level of social isolation.