Objective To understand the present situation of infectious disease outbreak coping ability of border nurses as well as its impact path, in order to provide reference for the promotion of nurses′ infectious disease outbreak coping ability.Methods Using multi-stage stratified cluster sampling method, 1,215 nurses from three cities (states) in the border region of Yunnan were selec-ted as the research participants.The Psychological Capital Questionnaire Revised (PCQ-R), Decent Work Perception Questionnaire (DWPS), and a questionnaire on healthcare workers′ ability to cope with infectious disease outbreaks were used to conduct the surveys.Results The scores of nurses′ psychological capital, decent work perception and infectious disease outbreak coping ability were (4.11±1.10), (3.48±0.81), and (3.55±0.96), respectively; psychological capital, decent work perception and infectious di-sease outbreak coping ability were positively correlated (P＜0.05 for all); psychological capital played a direct role in infectious disease outbreak coping ability, and decent work perception had a mediating role between psychological capital and infectious di-sease outbreak coping ability, with the mediating effect accounted for 49.34% of the total effect.Conclusion The psychological ca-pital, decent work perception and infectious disease outbreak coping ability of Yunnan border nurses are all at medium levels.Psychological capital and decent work perception have positive predictive effects on infectious disease outbreak coping ability, improving nurses′ psychological capital and decent work perception is an effective way to promote the infectious disease outbreak coping ability.