Objective To construct a traditional Chinese medicine (TCM) management program for lung cancer patients with chemotherapy intolerance and to explore the implementation effect.Methods A total of 130 lung cancer patients with chemotherapy into-lerance were divided into 65 cases each of routine group and observation group according to the admission time.The routine group was given routine nursing intervention; the observation group constructed and implemented the TCM management program.The effect was evaluated after 2 months of intervention.Results There were 62 cases in the observation group and 59 cases in the routine group who had completed the study.After the intervention, the TCM symptom score and chemotherapy tolerance score of the observation group were significantly lower than those of the control group, and the quality of life score was higher than that of the control group （all P＜0.05）.Conclusion TCM management can effectively improve the clinical symptoms of patients with chemotherapy intolerance, increase the tolerance to chemotherapy and improve the life quality of the patients.