Objective To analyze the influencing factors of respiratory movement artifacts in arterial phase in patients who underwent the hepatocyte-specific contrast agent enhanced magnetic resonance imaging (MRI), and to provide reference for targeted intervention to reduce the incidence of artifacts.Methods The clinical data of 233 inpatients who underwent the hepatocyte-specific contrast agent enhanced MRI for the first time were analyzed, retrospectively, and the risk factors of respiratory movement artifacts in arterial phase were determined by univariate and logistic regression analysis.Results Respiratory movement artifact in the arterial phase occurred in 30.90% of patients.Regression analysis showed that education level, body mass index (BMI), heart failure, chronic obstructive pulmonary disease, and ascites were the risk factors for respiratory movement artifacts in arterial phase of he-patocyte-specific contrast agent in MRI （all P＜0.05）.Conclusion The incidence of respiratory movement artifacts in arterial phase of hepatocyte-specific contrast agent enhanced MRI in patients is high, and there are many influencing factors.Prompt intervention should be made in high-risk patients to reduce the incidence of respiratory movement artifacts in the arterial phase.