Objective To explore the effects of stratified management of the health literacy to improve the level of health literacy, self-management capabilities, quality of life, and health outcomes of gout patients.Methods A total of 129 gout patients were divi-ded into a control group （n=64） and an intervention group （n=65） according to their admission dates.The control group was gi-ven routine gout care and follow-up, and the intervention group was given stratified management according to the results of health literacy screening and the grading of risk factors for patients′ disease states.The patients′ health literacy, self-management ability, quality of life scores and clinical indicators were compared before and after the intervention.Results There were 60 and 62 cases completed the study in the control group and the intervention group,respectively.After the intervention, the health literacy, self-management ability, and quality of life scores of the intervention group were significantly higher than those of the control group, and the blood uric acid and the number of gout attacks were significantly lower than those of the control group (all P＜0.05).Conclusion The implementation of stratified management based on health literacy can effectively improve the health literacy, self-ma-nagement ability and quality of life of gout patients, and improve the health outcomes of the patients.