Objective To explore the intervention effect of natural sound therapy on anxiety and depression of the pregnant women in third trimester and to promote their mental health.Methods A total of 60 pregnant women in third trimester were randomly divided into 30 each in the control group and the natural sound group.Pregnant women in the natural sound group listened to natural sounds for 20 min per day for 28 d.The control group rested quietly for the same period of time, the Self-Rating Anxiety Scale (SAS) and Self-Rating Depression Scale (SDS) were used to investigate the two groups of pregnant women before and after the intervention.Results There were 19 and 18 pregnant women completed the whole research process in the control and natural sound groups, respectively.Anxiety and depression scores of the natural sound group were significantly lower than those of the control group after the intervention （both P＜0.05）.Conclusion Natural sound intervention as a non-pharmacological approach can be effective in reducing an-xiety and depression during pregnancy.