Objective To investigate the current status and influencing factors of alexithymia in women assisting pregnancy through the in vitro fertilization-embryo transfer (IVF-ET), and to provide bases for clinical intervention.Methods A total of 294 women assisting pregnancy through the IVF-ET were surveyed by the general information questionnaire, Toronto Alexithymia Scale-20 (TAS-20), Patient Health Questionnaire-9 (PHQ-9) and the Infertility Stigma Scale (ISS).Results The total score of alexithymia of women assisting pregnancy through the IVF-ET was （55.53±9.15） points, and the incidence of alexithymia was 30.27%.The results of multiple linear regression analysis showed that education level, depression, and the stigma of infertility were the influencing factors （P＜0.05） for women assisting pregnancy through the IVF-ET, which could explain 35.1% of the total variation of the alexithymia.Conclusion Women assisting pregnancy through the IVF-ET have a higher level of alexithymia.It is recommended that clinical nursing staff should pay close attention to the emotional expression of the women assisting pregnancy, who usually with the low education, long time of infertility treatment, high level of depression, and high level of infertility stigma, and targeted psychological care should be implemented to help them alleviate depression and alexithymia.