Objective To explore the experience of decision-making regarding placement of central venous catheter among caregivers of children with cancer, and to provide evidence for decision-making support. Methods Using phenomenological qualitative design, purposive sampling was utilized to select 17 caregivers of children with cancer for semi-structured interviews.Data were analyzed using conventional content analysis method.Results Three themes and six sub-themes emerged: coexistence of active preparation and passive coping before decision-making （confusion and helplessness, positive coping）, coexistence of doctor-led and shared decision-making （doctor-led decision-making, shared decision-making）, coexistence of benefits and regrets after decision-making （be-nefits and gratitude, regrets and concerns）. Conclusion Caregivers of children with cancer have complex decision-making experience and low participation in decision-making regarding placement of central venous catheter.Medical staff should pay attention to their willingness to and factors associated with participation in shared decision-making, and provide targeted interventions, aiming to enhance caregivers′ willingness to participate in shared decision-making.