Objective To develop a psychological capital intervention protocol for couples of stroke patients, and to enhance their psychological capital.Methods Based on psychological capital intervention model and theory of dyadic illness management, an intervention protocol was developed after literature review, and then 18 experts were invited to participate in two rounds of Delphi consultation.Results All questionnaires were returned in each round, and the expert authority coefficient was 0.885.The final intervention protocol consisted of 8 sessions of intervention and 23 intervention measures. Conclusion The psychological capital intervention program for couples of stroke patients is scientific and recognized by experts.Further study would be taken to validate the effectiveness and feasibility in couples of stroke patients.