Objective Based on the "Practice Guideline for the Management of Iodinated Contrast Media Extravasation", this study aims to ensure the recommendations in the guideline can be effectively implemented in clinical practice, and to reduce the incidence of iodinated contrast media extravasation. Methods An evidence-based practice team was established to evaluate clinical applicability of the recommendations of the guideline, formulate the audit indicators, analyze barriers in clinical practice, develop and implement countermeasures.The incidence of iodinated contrast media extravasation, the execution rate of audit indicators by nurses, and the knowledge related to management of iodinated contrast media extravasation were compared before and after the evidence-based practice.Results The incidence of iodinated contrast media extravasation was 0.51% and 0.16% before and after the evidence-based practice, with significant difference （P＜ 0.05）.The execution rate of audit indicators by nurses and the knowledge of iodinated contrast media extravasation were significantly higher after the practice than the baseline values （both P＜0.05）.Conclusion Application of guideline-based strategies for the prevention and management of iodinated contrast media extravasation in clinical practice, can effectively improve nurses′ knowledge and adherence, resulting in reducing iodinated contrast media extravasation.